BioPortal FAQ

Frequently Asked Questions (FAQ)

General

NCBO

Advancing biology and medicine with tools and methodologies for the structured organization of knowledge.

What is NCBO?

The National Center for Biomedical Ontology (http://www.biontology.org) is a consortium of leading biologists, clinicians, informaticians, and ontologists who develop innovative technology and methods that allow scientists to create, disseminate, and manage biomedical information and knowledge in machine-processable form. Our vision is that all biomedical knowledge and data are disseminated on the Internet using principled ontologies, such that the knowledge and data are semantically interoperable and useful for furthering biomedical science and clinical care. The Center’s products and technologies include BioPortal, Phenote+, Open Biomedical Resources (OBR), Biomedical Annotations Repository (BAR), and Open Biomedical Data (OBD). Partner technologies include LexGrid, Protege, and Jambalaya. The products and technologies are used to deliver repositories and tools for accessing and using this biomedical information in research. The Center collaborates with biomedical researchers conducting Driving Biological Projects (DBPs) to enable their research and to stimulate technology development in the Center. The Center is undertaking outreach and educational activities to train the future generation of researchers in using biomedical ontologies and the Center’s tools to enhance scientific discovery.

What is an ontology?

An ontology is a formal representation of a set of concepts/nodes within a domain and the relationships between those concepts. It is used to reason about the properties of that domain, and may be used to define the domain.

Where are the ontologies?

Ontologies are available from BioPortal 2.0 at http://bioportal.bioontology.org.

How do I submit an ontology?

The current protocol is:

1) Go to BioPortal 2.0 at http://bioportal.bioontology.org

2) If you haven't already, click on the "Register" link in the top right hand corner.

3) After you have registered as a user, "Sign In" as that user.

4) Click on the "Browse" tab (or click on the following link: http://bioportal.bioontology.org)

5) Click on the "Submit Ontology" button and follow the instructions.

Ontology Content

Building Ontologies

How do I go about building an ontology?

There are a plethora of tools for building ontologies. Below are two preferred tools for building OWL and OBO ontologies:

1) Protege (http://protege.stanford.edu/) - OWL ontologies

2) OBOEdit (http://oboedit.org/) - OBO ontologies

What is the OBO Foundry?

A collaborative experiment, involving a group of OBO ontology developers who have agreed in advance to the adoption of a growing set of principles specifying best practices in ontology development. These principles are designed to foster interoperability of ontologies within the broader OBO framework, and also to ensure a gradual improvement of quality and formal rigor in ontologies, in ways designed to meet the increasing needs of data and information integration in the biomedical domain. See http://obofoundry.org/

NCBO Products

The NCBO has selected the Java/J2EE software infrastructure as the development of choice for all products.

What is BioPortal?

A web-based application for accessing, sharing, visualizing, analyzing, uploading, and searching a large repository of biomedical ontologies, terminologies, and annotations. BioPortal 2.0 is the current release accessible through the following URL: http://bioportal.bioontology.org/. To see a demo of BioPortal 2.0, please visit http://bioontology.org/videos/demos/BioPortal_2.0_Demo.html.

What is Open Biomedical Resources?

A set of annotations generated automatically. These annotations are presented through integration with BioPortal UI which enables researchers to search for biomedical resources associated (or annotated) with specific ontology terms.

What is Open Biomedical Services?

A set of inter-related Java-based REST/SOAP services that use ontologies in BioPortal to perform concept recognition, ontology traversal, concept expansion, and to determine concept similarity.

What is Biomedical Annotation Repository?

TBD

What is Phenote?

A Java client application for manual creation and storage of biomedical annotations (starting with phenotype annotations) using terms from multiple ontologies.

What is Open Biomedical Data?

A database of manually generated biomedical annotations (starting with phenotype annotations) summarizing key attributes such as anatomy, phenotype, and genetic features. The annotations are currently loaded directly from a Phenote file, which contains the manually created annotations.

incomplete is-a paths

Many OBO ontologies are currently incomplete with respect to all classes/terms having an is-a parent. Many tools (including OBO-Edit and AmiGO) deliberately allow the conflation of relations when presenting the ontology as a DAG or a tree to the user. However, other tools (including Protege and SWOOP) do not. This means that some OBO ontologies can look unusual when viewed with these other tools (lots of classes appear at the root level).

This is currently being addressed by the maintainers of OBO ontologies. An effort is underway to complete the is-a parentage in the GO cellular component ontology (biological process will be more difficult). The Plant Ontology Consortium are completing the is-a parentage in the plant anatomical structure ontology.

Until this work is complete, some OBO ontologies may look unusual when viewed in conventional ontology browsing and editing tools. With some of these tools, there may be some configurations which allow other relations to be conflated with the is-a relation when presenting the ontology as a DAG or tree view.

One option is to automatically create an is-a parent to the ontology root for every non-root class/term which lacks any is-a parents. Note that this may create inconsistencies in the ontology if the genuine is-a parent is somewhere deeper in the ontology hierarchy; nevertheless this step may be necessary before presenting some OBO ontologies to tools such as reasoners.

Details

Ontology Metadata

The NCBO is planning to leverage the Ontology Metadata Vocabulary (OMV) format to store all ontology meta data. Please see the following web site for more information on the format (http://omv.ontoware.org/).

OBO Format

Questions about the OBO text and xml formats

Is OBO Format different from the old GO format?

Yes. The old dag-edit format (i.e. the one in which indentation was used to denote the GO hierarchy) is STRONGLY deprecated.

Where can I find the spec?

You can find details on the 1.0 spec on the GO home page http://www.geneontology.org/GO.format.shtml#oboflat

This spec is somewhat underspecified

The 1.2 spec is in preparation, and will be released to coincide with the first production OBO-Edit release sometime early in 2006

You can find a preliminary version of the spec here: HTML -- http://www.godatabase.org/dev/doc/obo_format_spec.html PDF -- http://www.godatabase.org/dev/doc/obo_format_spec.pdf Ascii text -- http://www.godatabase.org/dev/doc/obo_format_spec.txt

Why not use XML?

There is also an obo-xml format. See

http://www.godatabase.org/dev/xml

Currently only available as DTD. Relax-NG and XSD coming soon.

Is there a UML model?

Yes, there is a UML translation of the obo format in progress, produced by Harold Solbrig of Mayo clinic; see:

http://informatics.mayo.edu/schema/OBO/UMLModel/HTML/

What tools support Obo-Format?

The following are *ontology* tools that support the OBO format. There are many other tools for the analysis of gene ontology data which also happen to read the OBO format - see http://www.geneontology.org/GO.tools.shtml for a list

OBO-Edit

(naturally!). You should use this rather than DAG-Edit (DAG-Edit still supports obo-1.0 format), as DAG-Edit is deprecated as of 2006.

COBRA

developed by Stuart Aitken as part of http://www.xspan.org. COBRA is a java ontology editor/viewer for aligning ontologies

go-perl

http://search.cpan.org/~cmungall/go-perl

Using Protege with OBO ontologies

You have two options here - use the Protege OBO plugin, or convert to a format which Protege understands.

The OBO plugin was developed at the University of Washington, and is no longer supported.

You can convert any obo-format file to OWL and use Protege-OWL (but not Protege-classic); see the next entry.

Note that when you look at many of the OBO ontologies in Protege (classic or Protege-OWL) you will see that there are large amounts of classes apparently at the root level. This is because OBO ontologies have historically not been complete with respect to all classes having a superclass (is-a parent). This is currently being addressed. See the FAQ entry on this subject.

Can I convert Obo-format to OWL?

Yes. At this present time, the best way of foing this is to use the xslts included in go-perl. Download and install: http://search.cpan.org/~cmungall/go-perl/ Then run the script

  go2owl myontology.obo

This functionality will soon be available from oboedit

For more details on the mapping, see:

http://www.fruitfly.org/~cjm/obol/doc/mapping-obo-to-owl.html

OK, but can I just download OBO ontologies as OWL without doing the conversion myself?

You can, at least for some OBO ontologies. This is an experimental service, and will eventually be subsumed into the services provided by cBio:

http://www.fruitfly.org/~cjm/obo-download

Can I convert Obo-format files to Protege-classic?

Not yet. In theory it should not be hard to provide an XSL for this. The reverse transformation may be more difficult.

OBD

What is OBD?

OBD is a database for storing data typed using OBO ontologies

Where is it?

In development!

Is there a demo?

See http://www.fruitfly.org/~cjm/obd

Datasets

See the above URL for now