Difference between revisions of "Workshop on Clinical Trial Ontology"
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The National Center for Biomedical Ontology will host a two-day workshop focused on the Ontology of Clinical Trials. The workshop will take place on May 16-17, 2007 at the NIH Campus in Bethesda, MD. | The National Center for Biomedical Ontology will host a two-day workshop focused on the Ontology of Clinical Trials. The workshop will take place on May 16-17, 2007 at the NIH Campus in Bethesda, MD. | ||
Revision as of 08:49, 2 May 2007
General Information
REGISTRATION FOR THIS EVENT IS NOW CLOSED!
The National Center for Biomedical Ontology will host a two-day workshop focused on the Ontology of Clinical Trials. The workshop will take place on May 16-17, 2007 at the NIH Campus in Bethesda, MD.
The meeting will be divided into two parts. Day 1 will be a public event consisting of presentations and panel discussions on the CTO and cognate initiatives. Day 2 will be a working meeting devoted to intense discussions of mature drafts of the CTO and to the creation of a strategy for its further development and testing.
The work of the NCBO is funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant 1 U 54 HG004028. Information on the National Centers for Biomedical Computing can be found here.
We are grateful to the National Heart, Lung and Blood Institute for generous support for this meeting.
Aim of the Workshop
The aim of the workshop is to foster the creation and dissemination of a reference ontology (high-quality controlled structured vocabulary) for the annotation of the results of clinical trials.
The Workshop will bring together representatives of all of the major groups involved in clinical trial informatics, design, execution, analysis and standardization, with the goal of achieving a broad consensus on the requirements which the ontology should address and on the most effective means of realizing these requirements.
Goals of the Clinical Trial Ontology Initiative
The proposed CTO should:
(1) fully and faithfully capture the types of entities and relationships involved in clinical trials of any experimental design
(2) comprehend terms like: cohort, randomization, placebo, response, efficacy, control, protocol, null hypothesis, confidence interval, finding, biomarker, primary outcome, secondary outcome, intervention group, experimental design, etc., including also major relevant statistical terms and terms drawn from resources such as the CDISC glossary and all terms needed for the task of meta-analysis of clinical trials;
(3) organize these terms in a structured way, providing definitions and logical relations designed to enhance retrieval of, reasoning with, and integration of the data annotated in its terms.
(4) support trial bank interoperation
(5) form an integral part of the more comprehensive framework of the Ontology for Biomedical Investigations OBI, which itself forms part of the OBO Foundry
(6) draw on and seek maximal alignment with existing clinical trial ontologies, including:
-- the Epoch ontology used by the Immune Tolerance Network
-- the RCT Schema ontology used by theTrial Bank Initiative
(7) rest on a clear understanding of the relation between CTO and an epidemiology study ontology
(8) rest on a clear understanding of the relation between CTO and data-model-oriented initiatives such as CDISC and BRIDG.
(9) meet the requirements of the OBO Foundry, and in particular support an adequate treatment of the distinction between types (surgical intervention, tumor, human being) and instances (Jane's oophorectomy, John's tumor, Fritz)
Agenda
May 16 Natcher Balcony A
8.00am Continental Breakfast & Registration
9.00am Carol Bean: Introduction
9.10am Susan Shurin, Deputy Director of the National Heart Lung and Blood Institute: Welcome
9.20am Werner Ceusters: How to Build an Ontology
10.00am Discussion
10.15am Refreshment Break
10.30am Chris Mungall: The OBO Foundry
11.00am Jennifer Fostel: The Ontology for Biomedical Investigations
11.30am Richard Scheuermann: Introducing the Clinical Trial Ontology
12.00pm Discussion
12.30pm Lunch Break
1.30pm Ida Sim: The RCT Schema
2.00pm Amar Das: Epoch: An Ontological Framework for Clinical Trial Management
2.30pm Barry Smith: The Clinical Trial Ontology: Creating Consensus
3.30pm Refreshment Break
4.00pm Discussion Session
5.00pm Close
May 17 Building 31 Conference Room 10
8.00am Continental Breakfast & Registration
9.00am Session 1: Building the Clinical Trial Ontology
Moderator: Richard Scheuermann
10.30am Refreshment Break
11.00am Session 2: Applying the Clinical Trial Ontology
Moderator: Alan Ruttenberg
12.30pm Lunch Break
1.30pm Session 3: The Future of the Clinical Trial Ontology
Moderator: Richard Scheuermann
3.00pm Refreshments/Close
Participants
Robert Arp -- NCBO, Buffalo, NY
Pat Avery -- Digital Infusion, Inc.
Elaine Ayres -- NIH / Clinical Center
William Barrick -- NIH/NIAID
Carol Bean -- NIH/NHLBI
Maureen Beanan -- NIH/National Center for Research Resources
Elmer Bernstam -- University of Texas Health Science Center at Houston
Olivier Bodenreider -- NIH/NLM
Olga Brazhnik -- NIH/National Center for Research Resources
Constantino Castillo -- The KEVRIC Company, Inc.
Werner Ceusters -- Ontology Research Group, University at Buffalo
Huey Cheung -- NIH/CIT
Ling Chin -- NIH / National Institute on Deafness and Other Communication Disorders
Chris Chute -- NCBO, Mayo Clinic, Rochester, MN
Christian Cocos -- IFOMIS, Saarbrücken, Germany
Elaine Collier -- NIH/National Center for Research Resources
Leo Cousineau -- Information Management Consultants, Reston, VA
Lindsay Cowell -- Duke University
Amar Das -- Stanford Medical Informatics
Kaushal Desai -- AstraZeneca
Stephen Dobson -- Pfizer Global Research and Development
Liju Fan -- Ontology Workshop, LLC
Kerstin Forsberg -- AstraZeneca
Jennifer Fostel -- NIH/NIEHS
Douglas Fridsma -- University of Pittsburgh
Charles P. Friedman -- NIH/CRIIT/NHLBI
Louis J. Goldberg -- University at Buffalo
Peter Good -- NIH/National Human Genome Research Institute
Norbert Graf -- Clinic for Paediatric Oncology and Haematology, Saarland University, Homburg, Germany
Lakshmi M. Grama -- NIH/NCI
Ted Grasela -- Cognigen Corporation, Amherst, NY
Patricia Haggerty -- National Heart, Lung and Blood Institute NHLBI / NIH
Herb Hagler -- University of Texas Southwestern Medical Center
Andrea Harabin -- National Heart, Lung and Blood Institute NHLBI / NIH
William Harlan -- Consultant, National Library of Medicine / NIH
Steve Harris -- Computing Laboratory, University of Oxford
Calvin A. Johnson -- Center for Information Technology CIT / NIH
Warren A. Kibbe -- Northwestern University
William Lau -- Center for Information Technology CIT / NIH
Jamie Lee -- University of Texas Southwestern Medical Center
Yuan Liu -- National Institute of Neurological Diseases and Stroke (NINDS) / NIH
Dan Lyman -- Information Management Consultants, Reston, VA
Charles Mead -- NIH/NCI Center for Biomedical Informatics and Information Technology
Ivan Montoya -- National Institute on Drug Abuse (NIDA) / NIH
Chris Mungall -- Howard Hughes Institute, Berkeley, CA
Robert A. Musson -- NIH / NHLBI
Fabian Neuhaus -– National Institute of Standards and Technology (NIST)
Eric Neumann -- Teranode, Seattle, WA
Jeng-Jong Pan -- National Institute on Drug Abuse (NIDA) / NIH
Dave Parrish -- Immune Tolerance Network, Pittsburgh, PA
Ricardo Pietrobon -- Duke University Medical Center
George O. Redmond -- National Cancer Institute (NCI) / NIH
Alexander Rosenthal -- National Institute of Allergy and Infectious Diseases (NIAID) / NIH
Alan Ruttenberg -- Science Commons (c/o MIT CSAIL)
Laurie M. Ryan -- National Institute on Aging (NIA) / NIH
Jody Sachs -- NIH/National Center for Research Resources
Michael Sayre -- NIH/National Center for Research Resources
Richard Scheuermann -- University of Texas Southwestern Medical Center
Susan Shurin -- National Heart, Lung and Blood Institute NIH / NHLBI
Hua-Chuan Sim -- National Library of Medicine NIH / NLM
Ida Sim -- Trial Bank, University of California at San Francisco Medical Center
Barry Smith -- NCBO, University at Buffalo, NY
Ranjana Srivastava -- Information Management Consultants, Reston, VA
Samson Tu -- Stanford University
Suresh Varghese -- Digital Infuzion, Inc.
Chunhua Weng -- University of Pittsburgh
Trish Whetzel -- University of Pennsylvania
Rebecca Williams -- National Library of Medicine / NIH
Sandhya Xirasagar -- Information Management Consultants, Reston, VA
Alison Yao -- National Institute of Allergy and Infectious Diseases, NIH / NIAID
Venue
Day 1: Balcony A, Building 45 (Natcher), NIH Campus, Bethesda, MD
Day 2: Conference Room 10, Building 31, NIH Campus, Bethesda, MD
Links
Ontology for Biomedical Investigations
The ACGT Project: Advancing Clinico-Genomic Trials on Cancer
A video introduction to ontologies by Barry Smith is available here:
- Realmedia: rtsp://stream.buffalo.edu/shared/research/phismith/Stanford10-25-06/Tutorial.rm
- Mediaplayer: rtsp://stream.buffalo.edu/shared/research/phismith/Stanford10-25-06/Tutorial.WMV
The second half of this presentation pertains to the building of the Clinical Trial Ontology.
Preliminary Fragment of CTO (for illustration purposes only)
